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Treatment Care Instruction

Text | Call | Message for follow up care clarification:

Ciara: 508-577-6385

Natasha: 617-955-4805

Administering Semaglutide via subcutaneous injection is a process that can be comfortably managed at home with proper instruction and practice. Here's a step-by-step guide to help ensure that you administer Semaglutide safely and effectively:

Before You Start

Check the Medication:

Do not use if the liquid is cloudy, colored, or contains particles. Please check with us with your medication. It is sometimes mixed with vitamin B, where the medication can be red, pink, or light pink in color. However, most of the time it is clear. This depends on the pharmacy.

Gather Supplies: You'll need your Semaglutide syringe, alcohol wipes, and a sharps disposal container.

Wash Your Hands: Thoroughly wash your hands with soap and water to minimize the risk of infection.

Preparing the Dose

Take medication from the Refrigerator: Remove the medication from the refrigerator.

Optionally, let it sit at room temperature for 10 to 15 minutes before use, depending on your comfort level.

Avoid Vigorous Shaking: Do not shake the syringe vigorously as it may cause bubbles. Lightly tap the syringe to remove small bubbles.

Prepare the Syringe: Pull back the syringe plunger slightly to prevent medication spillage. Gently push the liquid up close to the tip of the needle. Be cautious not to push the syringe too quickly to prevent medication from squirting out.

Choosing an Injection Site

Select an Area: The best sites for subcutaneous injections are your abdomen, thigh, or upper arm. Avoid areas that are bruised, tender, or scarred.

Rotate Sites: Rotate your injection sites with each dose to reduce the risk of tissue damage or irritation.

Injecting the Medication

1. Clean the Site: Wipe the chosen injection site with an alcohol wipe and let it air dry.

2. Prepare the Syringe: Remove the cap.

3. Insert the Needle: Pinch the skin lightly and insert the needle at a 90-degree angle. For thinner patients, a 45-degree angle may be more appropriate.

4. Inject the Medication: Push the plunger on the syringe slowly and steadily to inject the medication.

5. Finish: Wait for 5-10 seconds before removing the needle to ensure the full dose is delivered.

6. Dispose of the Needle: Immediately place the used needle in a sharps disposal container. Do not reuse needles.

After the Injection

Storage: Store the medication according to the manufacturer's instructions.

Monitor for Side Effects: Be aware of how you feel after the injection and report any side effects to Natasha,NP or Ciara,NP.


Avoiding Pain: Injecting into the abdomen, except for the 2-inch area around the navel, often results in less discomfort. The thigh and upper arm are also good sites but may be more sensitive.

Reducing Bruising: Do not rub the injection site after administering the shot to minimize bruising.

Remember, this guide provides a general overview. Always consult your healthcare provider for personalized advice and training on administering your injections.

Common Side Effects

Many of the side effects are related to the gastrointestinal system and may decrease as your body adjusts to the medication:




Abdominal pain


Reduced appetite

These symptoms are often mild to moderate and can decrease over time. Taking with food or at night may help mitigate some of these effects.

What to Do If You Experience Side Effects

If you experience any of the common side effects, discuss with your healthcare provider strategies to manage them, such as dietary adjustments or changing the timing of your dose. For any severe or persistent side effects, especially those listed under the serious category, seek medical attention immediately.

It's also important to have regular follow-up appointments with your healthcare provider to monitor your response to the medication and adjust the dose if necessary. Your healthcare provider can provide more detailed information on potential side effects and how to manage them based on your specific health situation.

Managing side effects, especially the more common gastrointestinal ones, involves a combination of adjusting lifestyle habits, dietary modifications, and sometimes, medical management. Here are strategies to help manage these side effects:

Gastrointestinal Side Effects

Start with a Low Dose: Beginning treatment with a low dose and gradually increasing it can help minimize gastrointestinal side effects such as nausea, vomiting, and diarrhea. This allows your body to adjust to the medication.

Eat Smaller, More Frequent Meals: Consuming smaller, more frequent meals can help reduce the severity of nausea and vomiting. Avoiding large meals can also prevent overloading the stomach.

Stay Hydrated: Especially if experiencing vomiting or diarrhea, it's crucial to stay hydrated. Drinking small sips of water or electrolyte-rich fluids throughout the day can help.

Avoid Fatty or Spicy Foods: These types of foods can exacerbate gastrointestinal discomfort. Opt for bland, easy-to-digest foods instead.

Ginger: Some people find that ginger can help reduce nausea. This can be in the form of ginger tea, ginger ale (ensure it's made with real ginger), or ginger chews.


Monitor Blood Sugar Levels: If you're taking GLP-1 / GIP medication with other diabetes medications, there's an increased risk of hypoglycemia. Regular monitoring can help you catch and treat low blood sugar early.

Have a Plan: Know the signs of hypoglycemia (shaking, sweating, hunger, dizziness, and confusion) and have a quick source of sugar available, such as glucose tablets or juice.


Increase Fluid Intake: Dehydration can occur, especially if experiencing vomiting or diarrhea. Aim to drink at least 8 glasses of water a day, more if you're losing fluids through vomiting or diarrhea.


Recognize the Symptoms: Be aware of the symptoms of pancreatitis, such as severe abdominal pain that may radiate to the back, nausea, and vomiting, and seek immediate medical attention if they occur.

Gallbladder Issues

Be Vigilant of Symptoms: Symptoms of gallbladder problems include pain in the upper right abdomen, fever, and jaundice. Prompt medical evaluation is necessary if these symptoms develop.

Managing Appetite Changes

Nutrient-Dense Foods: If experiencing reduced appetite, focus on nutrient-dense foods that provide adequate vitamins, minerals, and calories to meet your nutritional needs.

Allergic Reactions

Be Aware of Allergy Signs: Know the signs of an allergic reaction (rash, itching, swelling of the face, lips, tongue, or throat, difficulty breathing) and seek immediate medical help if they occur.

Psychological Support

Seek Support: Changes in weight, appetite, and lifestyle can be challenging. Support from healthcare providers, counselors, or support groups can be beneficial.

Regular Follow-Up

Keep Regular Appointments: Regular follow-up appointments with your healthcare provider are important to monitor your response to the medication, adjust doses if needed, and manage any side effects.

Adjusting the Medication

Dose Adjustments: Your healthcare provider may adjust your dose of Semaglutide or suggest taking it at a different time of day to help manage side effects.

It's important to communicate openly with your healthcare provider about any side effects you're experiencing. They can offer additional strategies or adjustments to your treatment plan to help manage side effects effectively.

If you experience severe side effects or an emergency after taking Semaglutide, go to the nearest emergency room or call 911 immediately.

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